The zebrafish as a vertebrate model organism has been used in numerous studies of the various aspects of neurogenesis. . The zebrafish as a model for nociception studies. attempts to identify the role of H6 homeobox (HMX) genes in early neural development, using the zebrafish as a model. Fast external development and transparency during embryogenesis allow for visual screening at the macroscopical and microscopical level, including visualization of organogenesis. How zebrafish mend the spinal cords: If nerve tracts in the animals are damaged, certain connective tissue cells, called fibroblasts (green), migrate to the wound and form scar tissue. Progress in Neuro-Psychopharmacology and Biological Psychiatry. In this regard, zebrafish are useful because the embryo is transparent, it develops outside of its mother, and its development from eggs to larvae happens in just three days. In contrast with mammals, the development of fish larvae occurs externally, making the zebrafish CNS accessible for experimental manipulation. Evidence-Based Complementary and Alternative Medicine. Research with this model has also expanded … As a vertebrate model organism, zebrafish provide a variety of advantages. Zebrafish models of cardiovascular disease. In Vivo Zebrafish models relevant to studying central opioid and endocannabinoid systems. Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is a prime model for genetic and developmental studies, as well as research in toxicology and genomics. Biochemical and Biophysical Research Communications. Similar to mice and fruit flies, zebrafish can be used for genetic analysis. IEEE/ACM Transactions on Computational Biology and Bioinformatics. New tides: using zebrafish to study renal regeneration. Our lab uses zebrafish to study the signaling mechanisms that determine heart size. development. Drug Screening to Treat Early-Onset Eye Diseases. A novel 3D method of locomotor analysis in adult zebrafish: Implications for automated detection of CNS drug-evoked phenotypes. Dopamine Inhibits Reproduction in Female Zebrafish (Danio rerio) via Three Pituitary D2 Receptor Subtypes. Real‐time imaging and genetic dissection of host–microbe interactions in zebrafish. . © 2011 Wiley‐Liss, Inc. Special Issue: Zebrafish Development: Basic Science to Translational Research (2). Real-time in vivo monitoring of circadian E-box enhancer activity: A robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. The zebrafish as a model for studying neuroblastoma. Toxicological and melanin synthesis effects of Polygonum multiflorum root extracts on zebrafish embryos and human melanocytes. Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach. Nanomaterial libraries and model organisms for rapid high-content analysis of nanosafety. Through a powerful combination of genetics and experimental embryology, significant inroads have been made into the regulation of embryonic axis formation, organogenesis, and the development of neural networks. Diving deeper into Zebrafish development of social behavior: Analyzing high resolution data. Regio- and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model. Zebrafish is emerging as a unique model organism for studying cancer genetics and biology. Abstract. The principle objective of this PA is to continue to promote the zebrafish as an animal model for the study of development, organ formation, behavior, aging, and disease research. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, Current Protocols Essential Laboratory Techniques, Current Protocols in Food Analytical Chemistry, Current Protocols in Magnetic Resonance Imaging, Current Protocols in Nucleic Acid Chemistry, I have read and accept the Wiley Online Library Terms and Conditions of Use. Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish. The zebrafish as a model for paediatric diseases. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Now it appears, the zebrafish can be used for high‐throughput screening (HTS) of drug libraries in the discovery process of promising new therapeutics. Gongal et al. Unlimited viewing of the article PDF and any associated supplements and figures. Novel models for assessing blood–brain barrier drug permeation. The zebrafish and zebrafish larva is a suitable model organism for drug discovery and development. Birth Defects Research (Part C) 93:268–280, 2011. As demonstrated through ongoing research programmes, the zebrafish model enables researcher… The ABCC6 Transporter as a Paradigm for Networking from an Orphan Disease to Complex Disorders. The zebrafish is a model organism used to study the development of vertebrates. Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, The fish embryo test (FET): origin, applications, and future. Zebrafish as an Zebrafish as model for studying human diseases No other vertebrate model organism’s popularity has grown as quickly as that of the zebrafish. Protective Effect and Mechanisms of New Gelatin on Chemotherapy-Induced Hematopoietic Injury Zebrafish Model. Swift Large-scale Examination of Directed Genome Editing. Zebrafish (Danio rerio) are small tropical fish (2.5-4 cm long) found natively in south Asia.First used in the 1960s in biological research, Zebrafish have proven to be excellent model organisms for developmental and disease studies. One unavoidable disadvantage of a relatively new model organism is just that; it is new. Advances in zebrafish chemical screening technologies. Advantages of using Zebrafish as a Model Organism. 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